The perfect activator for peptide synthesis at elevated temperatures.
OxymaPure® used with DIC produces peptides with increased yield and decreased epimerization when used as an alternative to HOBt.1 This safe, non-explosive auxiliary nucleophile works with carbodiimide coupling strategies to provide the best results for a peptide synthesis. Additionally, the use of DIC/Oxyma avoids side reactions associated with high levels of base (≥ 1 equiv. DIEA) using onium salt methods such as HBTU/DIEA.
- Extremely fast acylation rates
- Non-explosive (compared to HOBt)
- Low cost
- Highly soluble in peptide synthesis solvents
1. R. Subirós-Funosas, et al. (2009) Chem. Eur. J., 15, 9394.